Prof. Dominique Mazier
Dominique Mazier, is Professor of Parasitology/Mycology at University Pierre et Marie Curie (UPMC) School of Medicine and Head of the Parasitology/Mycology Department at Pitié-Salpêtrière University Hospital. She led several INSERM research units since 1997. She has been instrumental in establishing in vitro and in vivo models of malaria pre-erthrocytic stages. These models have been allowed for the analysis of host immune responses and identification of host molecules that are crucial for hepatic development of the Plasmodium parasite including CD81 and SRB1. These platforms also allow for high-throughput screening efforts to identifying novel drugs against Plasmodium liver stages. More recently her group has developed a novel in vitro model of infection with the simian malaria parasite Plasmodiumcynomolgi for the study of hypnozoites. This model is currently being exploited to characterize the mechanisms of dormancy and reactivation, and for the screening of drugs active on hypnozoites.