Prof. Stefan Kappe

Stefan Kappe is a Professor at Seattle Biomedical Research Institute and an Affiliate Professor of the Department of Global Heath at the University of Washington. His laboratory research is focused on the biology of the parasites sporozoite transmission stages and the liver stages in the mammalian host. The goal of the lab is to understand molecular mechanisms of hepatocyte infection and liver stage parasite development and elucidate networks of host-parasite interactions during liver stage infection. The Kappe lab also investigates immune responses to pre-erythrocytic stages with the goal of gaining mechanistic insights into protective innate and adaptive immunity. The lab utilizes this knowledge to enable the development of new malaria interventions, both drugs and vaccines. Professor Kappe has pioneered the design of genetically engineered, live attenuated malaria parasite strains for vaccination.


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