Dr. Adele Lehane
Adele is a Research Fellow at the Australian National University. Her PhD, performed under the supervision of Prof. Kiaran Kirk at the ANU, was on the mechanism of chloroquine resistance in P. falciparum. Immediately following her PhD, Adele relocated to Prof. David Fidock’s laboratory at Columbia University, New York, for two years (2010-2012) on an NHMRC Overseas Biomedical Fellowship. The Australia-based years of the fellowship (2012-2014) were then undertaken in Prof. Kiaran Kirk’s laboratory. Adele uses a variety of physiological and biochemical techniques to study the mechanisms of action of, and resistance to, antimalarial drugs. She devised a live-cell fluorescence-based assay for monitoring the efflux of drugs from the digestive vacuole of intact malaria parasites, and uses this system to study the interactions of compounds with the P. falciparum Chloroquine Resistance Transporter. Her recent research has focused on parasite ion regulation, with a particular emphasis on the vulnerable drug target PfATP4.